Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions
نویسندگان
چکیده
منابع مشابه
Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.
Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate drug influx (phase 0) and drug/drug-metabolite efflux (phase III). Genes involved in drug metabolism and disposition are induced by xenobiotic-activated nuclear receptors (NRs), i.e. PXR (pregnane X receptor) and CAR ...
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ژورنال
عنوان ژورنال: Nuclear Receptor Research
سال: 2015
ISSN: 2314-5714,2314-5706
DOI: 10.11131/2015/101178